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In 2011, Dr. Dena Dubal was hired by the University of California, San Francisco, as an assistant professor of neurology. She set up a new lab with one chief goal: to understand a mysterious hormone called Klotho. Dr. Dubal wondered if it might be the key to finding effective treatments for dementia and other disorders of the aging brain. At the time, scientists only knew enough about Klotho to be fascinated by it. Mice bred to make extra Klotho lived 30 percent longer, for instance. But scientists also had found Klotho in the brain, and so Dr. Dubal launched experiments to see whether it had any effect on how mice learn and remember. (Zimmer, 4/2)

Dr. Michael Ehlers, Biogen’s head of research, said Monday that the company is “looking very closely” at the data on aducanumab, an Alzheimer’s drug meant to slow the disease by targeting sticky brain plaques called beta-amyloid. Last month, Biogen terminated two large studies of aducanumab after determining that the drug had no hope of succeeding. Now Biogen must decide what that failure means for the rest of its work in Alzheimer’s, a ruling Ehlers said will arrive “in the coming weeks.” (Garde, 4/1)

In Boston's federal courthouse, prosecutors spent two months calling witness and laying out their argument in the criminal case against Insys Therapeutics founder and onetime billionaire, John Kapoor, and four of his former employees. The defense could begin presenting its case Monday. If convicted, the opioid entrepreneur could face up to 20 years behind bars. Kapoor and his co-defendants are accused of racketeering, a charge often applied to drug kingpins and mafia bosses. (Emanuel, 4/1)

Kaiser Health News: Elite Hospitals Plunge Into Unproven Stem Cell Treatments

The online video seems to promise everything an arthritis patient could want. The six-minute segment mimics a morning talk show, using a polished TV host to interview guests around a coffee table. Dr. Adam Pourcho extols the benefits of stem cells and “regenerative medicine” for healing joints without surgery. Pourcho, a sports medicine specialist, says he has used platelet injections to treat his own knee pain, as well as a tendon injury in his elbow. Extending his arm, he says, “It’s completely healed.” (Szabo, 4/2)

Under pressure from federal regulators and some investors, Walgreens Boots Alliance Inc. is testing tobacco-free stores in the U.S., but the pharmacy chain’s leader has no plans to quit selling cigarettes entirely. “The safety of our patients is very important, but we also have to do what our customers are requiring us to do,” Walgreens Boots Chief Executive Stefano Pessina said in a recent interview. “We see that when we don’t sell tobacco, we have a lot of [negative] reactions.” (Al-Muslim, 3/31)

An 8-year-old Guatemalan boy who died while in custody of the U.S. border patrol on Christmas Eve died of the flu and a bacterial infection, authorities in the Central American nation said Monday. Oscar Padilla, Guatemalan consul in Phoenix, Arizona, told The Associated Pres that the autopsy report on Felipe Gomez Alonzo was delivered in recent days and had found he died from the infection and "complications from influenza B." (4/1)

Omega-3 fatty acids in foods may reduce symptoms of childhood asthma, while omega-6 fats may aggravate them, a small study suggests. Omega-3s are found in high concentrations in fish and walnuts. Omega-6 sources include corn oil and other vegetable oils. Some foods contain both. (Bakalar, 4/1)